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穿膜肽修饰

将药物分子引入细胞的过程一直是科研工作者面临的一个重要挑战,然而,穿膜肽(CPPs)却有穿过细胞膜的能力,但是又不需要依靠膜受体。穿膜肽通常由10-30个带正电荷的氨基酸组成。穿膜肽(CPPs)可以将具有生物活性的药物分子传递到细胞内部。我们可以将我们想要的药物分子结合到穿膜肽(CPPs)上,然后传递到细胞内的目标靶点,以此克服细胞膜带来的通过障碍。穿膜肽(CPPs)作为非病毒类穿膜载体受到了科研工作者的普遍欢迎。虽然他们成功的将其应用于转运各种不同大小的药物分子(质粒,多肽,蛋白,纳米粒子等),但是最快速的还是应用在寡聚核苷酸(ONs)的转运上。 鸿肽生物已经合成了大量的穿膜肽,下面是一些已知的穿膜肽序列:
点击下载穿膜肽列表

名称

2

18A

α1H

α2H

A22p

Ac-18A-NH2

aCPP

AdVpVI(33-55)

AIP6

all-d DsC18

αgliadin(31-43)

Alyteserin-2a

ANG

ApoE(141–150)

ApoE-derived

Arf(1-22)

AT1002

AT1AR(304-318)

Bac7

BGPC7-FHV

Bim

BP16

BP100

BPP13a

bPrPp(1-30)

BR2

Buforin II

Buforin IIb

C6M1

C105Y

CADY

CAR

CA-Tat

CB5005 M

CDB3

CendR

cFΦR4

CGKRK

CIGB-300

CIGB-552

CLIP6

CooP

CpMTP

CPNT

CPP1

CPP33

CPP-C

CPPecp

C-peptide

CRGDK

Crotamine

cSN50

65-2CTS

CWR8K

CyLoP-1

Cyt c(77–101)

DAG

D-JNKI-1

DK17

DLP

DMBT1-derived

dNP2

DPV3

DPV1047

DRTTLTN

DS4.3

Dynorphin A

EA

EB1

EF

EHB

EPRNEEK

F3**

G4R9L4

GALA

GeT

gH625

Gi3α(346-355)

Glu-Lys

GV1001

GWH1

H2A derived

H6R6

H16

HA2(1-23)

HAIYPRH

hBD3-3

HBP

hLF

Hph-1

HR9

Hst5

I1WL5W

I4WL5W

ID No.2

IMT-P8

INF

iNGR

isl-1

JB9

JB434

KAFAK

KALA

Kalata B1

(KFF)3K

K-FGF

KH

KLA

KLAK

KLA-R7

KP

KST peptide

L1−6

L5a

L17E

lactoferrampin(265- 284)

lactoferricin(17-30)

lactoferrin(19-40)

LAH1

LALF(31-52)

LB

L-CPP

LDP-NLS

LE10

LF chimera

linTT1

LK

LL37

LLIIL

LMWP

LP-12

LPAs

LTV

lycosin-I

Lyp1

M918

Maurocalcine

MAP

MAP12

MCoTI-I

MCoTI-II

MFK

Mgpe9

MitP

m(KLA)-iRGD

MMGP1

MPER fragment

MPG

MPG

MPG-8

mRVG

MT23

mtCPP1

MTM

MTD84

MTP

MTS

MTS1

Mut3DPT-C9h

Myr-ApoE

New modalities

NF1

NF51

NF55

NLS

NLS-StAx-h

NoLS

Novicidin

NPFSD

NYAD-1

Oct4-PTD

P007

P1

P2

P3

P7

P11

P11

P11LRR

P14LRR

p18

P21

P28

p28

p53 peptide MO6

PAF26

PAS

pCLIP6

pD-SP5

PenetraMax

Penetratin

Pep-1

pepM

pepR

Pept1

Peptide 599

Pep42

PepNeg

PepFect6

PepFect14

PG1

pHLIP

PHPs

PIP1

Pip5e

Pip6a

POD

PR9

PTD

PTD3

PTD4

Poly-Arg

pVEC

Pyrrhocoricin

R4K1

R6dGR

R8

R8-dGR

R9-H4A2

R6W3

R10W6

RA9

RALA

RDP

REDV

RF

cRGDfC

iRGD

RGE

RH9

RL9

RL16

RT53

RTP004

RV24

RVG

RVG-9R

RVG29

RW9

RW16

(RXR)4

(rXr)4

S155

S4(13)-PV

SAP

SAP(E)

all-D-SAP

SAPSp-lipo

SAR6EW

sC18

(sC18)2

SMTP motif,

SPACE

SRCRP2-11

STR-KV

SS-02

SS-20

SS-31

SynB1

T2

Tat(49-57)

Tat(48-60)

Tat(44-57)

Tat(37-72)

Tat analog

Tat-LK15

TCTP

TD-1

TD2.2

TH peptide

TM2

Transportan

TP10

TPk

Tpl

TPP

TT1

vAMP 059

vCPP 0769

vCPP 2319

VDAC(1-26)

VP22

V peptide

VT5

W(RW)4

Xentry

X-pep

YKA

YTA2

YTA4

Z2

Z3

Z12

ZXR-1

序列

DSLKSYWYLQKFSWR (Kondo et al. 2012)

DWLKAFYDKVAEKLKEAF (Datta et al. 2000)

KSKTEYYNAWAVWERNAP (Gomarasca et al. 2017)

GNGEQREMAVSRLRDCLDRQA (Gomarasca et al. 2017)

HTPGNSNKWKHLQENKKGRPRR (Shin et al. 2014)

DWLKAFYDKVAEKLKEAF) (Wimley and White 2000)

Typical sequence R9GPLGLAGE8 (Li et al 2015)

Ac-GAFSWGSLWSGIKNFGSTVKNYG (Murayama et al. 2016)

RLRWR (Wang et al. 2011)

Glrkrlrkfrnkikek (Bergmann et al. 2017)

LGQQQPFPPQQPY (Paolella et al. 2018)

ILGKLLSTAAGLLSNL (Conlon et al. 2013)

TFFYGGSRGKRNNFKTEEY (Demeule et al. 2008)

Ac-LRKLRKRLLRX-Bpg-G (Shabanpoor et al. 2017)

Ac-LRKLRKRLLR (Tailhades et al. 2017)

MVRRFLVTLRIRRACGPPRVRV (Johansson et al. 2008)

FCIGRL (Gopalakrishnan et al. 2009)

FLGKKFKKYFLQLLK (Östlund et al. 2005)

RRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPL (Sadler et al. 2002)

RRRRNRTRRNRRRVR-RRFYGPV (Wongso et al. 2017)

EIWIAQELRRIGDEFNAYYARLLC (Kim et al. 2017)

KKLFKKILKKL (Soler et al. 2014)

KKLFKKILKYL (Eggenberger et al. 2009)

GGWPRPGPEIPP (Sciani et al. 2017)

MVKSKIGSWILVLFVAMWSDVGLCKKRPKP (Magzoub et al. 2006)

RAGLQFPVGRLLRRLLR (Lim et al. 2013)

TRSSRAGLQFPVGRVIIRLLRK (Park et al.1998)

RAGLQFPVG[RLLR]3 (Lee et al. 2008)

RLWRLLWRLWRRLWRLLR (Jafari et al. 2014)

CSIPPEVKFNKPFVYLI (Rhee and Davis 2006)

GLWRALWRLLRSLWRLLWRA cycteamide (Crombez et al. 2009a)

CARSKNKDC (Toba et al. 2014)

KWKLFKKYGRKKRRQRRR (Lv et al. 2017)

KLKLALALALA (Zhang et al. 2016)

REDEDEIEW (Issaeva et al. 2003)

RPARPAR (Hu et al. 2014)

cyclic FΦRRRRQ (Qian et al. 2014)

CGKRK (Griffin et al. 2017)

cyclic CWMSPRHLGTC-Tat (Perera et al. 2012)

Ac-HARIKpTFRRlKWKYKGKFW (Fernandez Masso et al. 2013)

KVRVRVRVpPTRVRERVK (Soudah et al. 2017)

ACGLSGLGVA (Hyvonen et al. 2014)

ARLLWLLRGLTLGTAPRRA (Jain and Chugh 2016)

STSGTGKMTRAQRRAAARRNRA (Qi et al. 2011)

(KFF)3K (Patel et al. 2017)

RLWMRWYSPRTRAYG (Lin et al. 2018)

PIEVCMYREP (Nakayama et al. 2011)

NYRWRCKNQN (Fu et al. 2017)

GPGLWERQAREHSERKKRRRESECKAA (Fan et al. 2016)

CRGDK (Zhao et al. 2018)

YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSG(Rodrigues et al. 2012)

AAVALLPAVLLALLAPVQRKRQKLMP (Torgerson et al. 1998)

CPYVNQRPQKARYRNG (Percipalle et al. 2003)

CWR8K (Sasaki et al. 2008)

CRWRWKCCKK (Ponnappan et al. 2017)

GTKMIFVGIKKKEERADLIKKA (Howl and Jones 2015)

cyclic CDAGRKQKC (Mann et al. 2017)

RPKRPTTLNLFPQVPRSQDT (Bonny et al. 2001)

DRQIKIWFQNRRMKWKK (Bera et al. 2016)

ACKTGSHNQCG (Kumar et al. 2015)

GRVEVLYRGSW and GRVRVLYRGSW (Tuttolomondo et al. 2017)

KIKKVKKKGRK-KIKKVKKKGRK (Lim et al. 2015)

RKKRRRESRKKRRRES (Tacken et al. 2008)

CVKRGLKLRHVRPRVTRMDV (De Coupade et al. 2005)

DRTTLTN (Gennari et al. 2016)

RIMRILRILKLAR (Jeong et al. 2014)

YGGFLRRIRPKLKWDNQ (Marinova et al. 2005)

GLKKLAELAHKLLKLGC (Yang et al. 2014)

LIRLWSHLIHIWFQNRRLKWKKK (Lundberg et al. 2007)

GLKKLAELFHKLLKLGC (Yang et al. 2014)

RCSHYTGIRCSHMAATTAGIYTGIRCQHVVL-C6H (Cao et al. 2018)

EPRNEEK (Orihuela et al. 2009)

diphosphorylated dipeptide (Miao et al. 2016)

G4R9L4 (Ramakrishna et al. 2014)

WEAALAEALAEALAEHLAEALAEALEALAA (Li et al. 2004)

KIAKLKAKIQKLKQKIAKLK (Rakowska et al. 2014)

HGLASTLTRWAHYNALIRAF (Galdiero et al. 2015)

KNNLKECGLY (Jones et al. 2005)

EEEAAKKK (Lewis et al. 2010)

EARPALLTSRLRFIPK (Kim et al. 2016a)

GYNYAKKLANLAKKFANALW (Serna et al. 2017)

SGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKG(Rosenbluh et al. 2004)

H6R6 (Sun et al. 2017)

H16 (Iwasaki et al. 2015)

GLFGAIAGFIENGWEGMIDGWYG (Esbjörner et al. 2007)

HAIYPRH (Shteinfer-Kuzmine et al. 2017)

GKCSTRGRKCCRRKK (Lee et al. 2015b)

GKRKKKGKGLGKKRDPCLRKYK (Luo et al. 2016)

KCFQWQRNMRKVRGPPVSCIKR (Duchardt et al. 2009)

YARVRRRGPRR (Jung et al. 2011)

CH5-R9-H5C (Liu et al. 2013a)

DSHAKRHHGYKRKFHEKHHSHRGY (Luque-Ortega et al. 2008)

WKKIWSKIKKLLK (Bi et al. 2014)

IKKWWSKIKKLLK (Bi et al. 2014)

MAAWMRSLFSPLKKLWIRMH (Eudes and Macmillan 2014)

RRWRRWNRFNRRRCR (Gautam et al. 2016)

GLFEAIEGFIENGWEGMIDGWYGC (Pichon et al. 1997)

CRNGRGPDC (Alberici et al. 2013)

RVIRVWFQNKRCKDKK (Kilk et al. 2001)

cskc (Basu and Wickstrom, 1997)

R9GGLAA-Aib-SGWKH6 (Sangtani et al. 2018)

KAFAKLAARLYRKALARQLGVAA (Bartlett et al. 2013)

WEAKLAKALAKALAKHLAKALAKALKACEA (Wyman et al. 1997)

polycyclic CGETCVGGTCNTPGCTCSWPVCTRNGLPV (Daly et al. 1999)

(KFF)3K (Rownicki et al. 2017)

AAVLLPVLLAAP (Lin et al. 1995)

(KH)9 (Chuah et al. 2016)

KLAKLAKKLAKLAK (Huang et al. 2017)

KLALKLALKALKAALKLA (Oehlke et al. 1998)

KLAKLAKKLAKLAKGGRRRRRRR (Lemeshko, 2013)

MAPTKRKGSCPGAAPNKKP (Villa-Cedillo et al. 2017)

STGKANKITITNDKGRLSK (Adachi et al. 2017)

PLILLRLLR (Schmidt et al. 2017)

RRWQW (Liu et al. 2016a)

IWLTALKFLGKHAAKHEAKQQLSKL (Akishiba et al. 2017)

DLIWKLLSKAQEKFGKNKSR (Reyes-Cortes et al. 2017)

FKCRRWQWRMKKLG (Reyes-Cortes et al. 2017)

KCFMWQEMLNKAGVPKLRCARK (Duchardt et al. 2009)

KKLALALALALHALALALALKKA (Moulay et al. 2017)

HYRIKPTFRRLKWKYKGKFW (Yanez et al. 2017)

FKCRRWQWRMKKLGAPSITCVRRAF) (Liu et al. 2013b)

LAGRRRRRRRRRK (Liu et al. 2006)

KWRRKLKKLRPKKKRKV (Ponnappan and Chugh, 2017)

LELELELELELELELELELE (Antunes et al. 2013)

FKCRRWQWRMKKLG-K-RSKNKGFKEQAKSLLKWILD(Reyes-Cortes et al. 2017)

AKRGARSTA (Hunt et al. 2017)

LKKLLKLLKKLLKLAG (Kim et al. 2016b)

LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES (Kim et al. 2016b)

LLIIL (Alaybeyoglu et al. 2017)

VSRRRRRRGGRRRR (Chen et al. 2017d)

HIITDPNMAEYL (Kumar et al. 2015)

RCnRCnK (Gupta et al. 2011)

LTVSPWY (Chopra 2012)

RKGWFKAMKSIAKFIAKEKLKEHL (Tan et al. 2017)

CGNKRTRGC (Fogal et al. 2008)

MVTVLFRRLRIRRACGPPRVRV (El-Andaloussi et al. 2007)

GDCLPHLKLCKENKGCCSKKCKRRGTNIEKRCR (Poillot et al. 2010)

KLALKLALKALKAALKLA (Oehlke et al. 1998)

LKTLTETLKELTKTLTEL (Oehlke et al. 2002)

polycyclic SGSDGGVCPKILQRCRRDSDCPGACICRGNGYCG(Camarero, 2017)

polycyclic CPKILKKCRRDSDCPGACICRGNGYCGSGSDGGV(Huang et al. 2015)

MFKLRAKIKVRLRAKIKL (Samuels et al. 2017)

CRRLRHLRHHYRRRWHRFRC (Vij et al. 2016a)

INLKKLAKL(Aib)KKIL (Howl et al. 2018)

klaklakklakla-K-GG-iRGD (Qifan et al. 2016)

MLWSASMRIFASAFSTRGLGTRMLMYCSLPSRCWRK(Pushpanathan et al. 2013)

ELDKWASLWNWFDITNWLWYIK (Song et al. 2009)

GALFLGFLGAAGSTMGA cysteamide (Morris et al. 1997)

GALFLGFLGAAGSTMGASQPKKKRKV cycteamide (Deshayes et al. 2005)

AFLGWLGAWGTMGWSPKKKRK (Crombez et al. 2009b)

YTIWMPENPRPGTPCDIFTKSRGKRASNGGGRRRRRRRRR(Villa-Cedillo et al. 2017)

LPKQKRRQRRRM (Zhou et al. 2017)

r-Dmt-OF (Cerrato et al. 2015)

AAVALLPAVLLALLAP (Fletcher et al. 2010)

AVALVAVVAVA (Lim et al. 2014)

MLSLRQSIRFFK (Chuah et al. 2015a, b)

KGEGAAVLLPVLLAAPG (Zhao et al. 2001)

AAVLLPVLLAAP (Rojas et al. 1998)

VKKKKIKAEIKIYVETLDDIFEQWAHSEDL (de la Torre et al. 2017)

Myr-LRKLRKRLLR (Tajik-Ahmadabad et al. 2017)

Polycyclic, hairpin, stapled peptides for delivery (Valeur et al. 2017, Waldmann et al. 2017)

Stearyl-AGY(PO3)LLGKTNLKALAALAKKIL (Arukuusk et al. 2013)

δ-(Stearyl-AGYLLG)OINLKALAALAKKIL (Arukuusk et al. 2013)

δ-(Stearyl-AGYLLG)OINLKALAALAKAIL (Freimann et al. 2016)

PKKKRKV (Yoneda et al. 1992).

stapled RRWPRXILDXHVRRVWR (Dietrich et al. 2017)

KKRTLRKNDRKKRC (Yao et al. 2015)

KNLRRIIRKGIHIIKKYF (Milosavljevic et al. 2016)

VLTNENPFSDP (Gong et al. 2016)

stapled ITFEDLLDYYGP (Zhang et al. 2008)

DVVRVWFCNRRQKGKR (Adachi et al. 2017)

Ac-(RAhxR)4-Ahx-βAla (Greer et al. 2014)

LRRWSLG (Peng et al. 2017b)

WKRTLRRL (Peng et al. 2017b)

YGRKKRRQR (Tan et al. 2006)

RRMKWKK (Watson et al. 2017)

YGRKKRRQRRR (Zhao et al. 2011)

HSDVHK (Bang et al. 2011)

P11LRR (Li et al. 2010)

(PLPRPR)4 (Brezden et al. 2016)

LSTAADMQGVVTDGMASG (Taylor et al. 2009)

KRKKKGKGLGKKRDPCLRKYK (Dixon et al. 2016)

LSTAADMQGVVTDGMASGLDKDYLKPDD, Leu50-Asp77 of azurin (Yamada et al. 2016)

FLHSGTAVTCTYPALTPQWEGSDCTHRL (Signorelli et al. 2017)

Stapled TSF*EYWYLL* (Chee et al. 2014)

Ac-rkkwfw (Lopez-Garcia et al. 2002)

GKPILFF (Woldetsadik et al. 2017)

KVRVRVRVpP(pT)RVRERVK (Chen et al. 2017b)

riPRPSPKMGV(pS)VS (Chen et al. 2017b)

KWFKIQMQIRRWKNKR, L- and D- (Khafagy el et al. 2015)

RQIKIWFQNRRMKWKK (Derossi et al. 1994)

KETWWETWWTEWSQPKKKRKV cysteamide (Morris et al. 1997)

KLFMALVAFLRFLTIPPTAGILKRWGTI (Freire et al. 2014)

LKRWGTIKKSKAINVLRGFRKEIGRMLNILNRRRR (Freire et al. 2014)

PLILLRLLRGQF (Marks et al. 2011)

GLFEAIEGFIENGWEGMIDGWYGGGGRRRRRRRRRK(Alexander-Bryant et al. 2015)

Cyclic CTVALPGGYVRVC (Kim et al. 2006)

SGTQEEY (Neves-Coelho et al. 2017)

Stearyl-AGYLLGK(εTMQ)INLKALAALAKKIL, PF6 (El-Andaloussi et al. 2011)

Stearyl- AGYLLGKLLOOLAAAALOOLL (Ezzat et al. 2011)

RGGRLCYCRRRFCVCVGR (Liu et al. 2013b)

AEQNPIY-WARYADWLFTTPLLLLDLALLV-DADEGT (Andreev et al. 2010)

H6-H10 peptides (Kimura et al. 2017)

RXRRXRRXRIKILFQNRRMKWKK (Ivanova et al. 2008)

RXRRBRRXRILFQYRXRBRXRB (Betts et al. 2012)

Ac-RXRRBRRXRYQFLIRXRBRXRB (Lehto et al. 2014)

CGGG(ARKKAAKA)4 (Dasari et al. 2017)

FFLIPKG-R9 (Liu et al. 2013a)

YARVRRRGPRRR (Dong et al. 2016)

R9-ETWWETWWTEW (Kizaka-Kondoh et al. 2009)

YARAAARQARA (McCusker et al. 2007)

Most popular R7 - R12 (Mitchell et al. 2000, Futaki, 2006)

LLIILRRRIRKQAHAHSK (Elmquist et al. 2001)

VDKGSYLPRPTPPRPIYNRN (Otvos et al. 2000)

Stapled Ac-RRRRKS*LHRS*LQDS (Speltz et al. 2018)

R6dGR (Wang et al. 2017)

R8 (Wender et al. 2001)

R8dGR (Liu et al. 2016b)

Ac-YR9-HAHAHH (Okitsu et al. 2017)

R6W3 (Bechara et al. 2013)

R10W6 (Bechara et al. 2013)

RRAARRARR (Alhakamy et al. 2013)

WEARLARALARALARHLARALARALRACEA (McCarthy et al. 2014)

CKSVRTWNEI IPSKGCLRVG GRCHPHVNGG GRRRRRRRRC(Xiao et al. 2017)

REDV (Yang et al. 2016)

GLKKLARLFHKLLKLGC (Yang et al. 2014)

Cyclic RGDfC (Wada et al. 2017)

Cyclic CRGDKGPDC (Peng and Kopecek, 2015)

RGERPPR (Yu et al. 2017)

RRHHRRHRR (Alhakamy et al. 2013)

RRLLRRLRR (Alhakamy et al. 2013)

RRLRRLLRRLLRRLRR (Joanne et al. 2009)

RQIKIWFQNRRMKWKKAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKT (Jagot-Lacoussiere et al. 2016)

RKKRRQRRRG-K15-GRKKRRQRRR) (Lee et al. 2015a)

RRRRRRRRRGPGVTWTPQAWFQWV (Lo and Wang, 2012)

YTIWMPENPRPGTPCDIFTNSRGKRASNG (Kumar et al. 2007)

YTIWMPENPRPGTPCDIFTNSRGKRASNGGGGRRRRRRRRR(Rassu et al. 2017)

YTIWMPENPRPGTPCDIFTNSRGKRASNGGGGRRRRRRRRR(Villa-Cedillo et al. 2017)

RRWWRRWRR (Alhakamy et al. 2013)

RRWRRWWRRWWRRWRR (Jobin et al. 2013)

(R-Ahx-R)4 (Saleh et al. 2010)

(r-Ahx-r)4 (Vij et al. 2016b)

VKKKKIKREI-KIAAQRYGRELRRMADEFHV (Haidar et al. 2017)

ALWKTLLKKVLKAPKKKRKV (Mano et al. 2007)

VRLPPPVRLPPPVRLPPP (Pujals et al. 2006)

VELPPPVELPPPVELPPP (Martin et al. 2011)

(vrlppp)3 (Pujals et al. 2007)

stearyl-GGGGHGAHEHAGHEHAAGEHHAHE (Suzuki et al. 2017)

SAR6EW (Im et al. 2017)

GLRKRLRKFRNKIKEK (Oren et al. 1999)

(GLRKRLRKFRNKIKEK)2 (Gronewold et al. 2017)

LRLLR (Fuselier and Wimley, 2017)

Cyclic ACTGSTQHQCG (Hsu and Mitragotri, 2011)

GRVEVLYRGSW (Tuttolomondo et al. 2017)

H3K3V6 (Pan et al. 2016)

Dmt-r-FK (Alta et al. 2017)

F-r-FK (Alta et al. 2017)

r-Dmt-KF (Zhao et al. 2005)

RGGRLSYSRRRFSTSTGR (Rousselle et al. 2000)

LVGVFH (Kumar et al. 2012)

RKKRRQRRR (Vives et al. 1997a)

GRKKRRQRRRPPQ (Vives et al. 1997b)

CGISYGRKKRRQRRR (Niesner et al. 2002)

CFITKALGISYGRKKRRQRRRPPQGSQT-HQVSLSKQ (Fawell et al. 1994)

GRKKRRQR (Nguyen et al. 2008)

Tat-KLLKLLLKLLLKLLK (Peng et al. 2017a)

MIIFRALISHKK (Bae et al. 2016)

ACSSSPSKHCG (Chen et al. 2006)

SYWYRIVLSRTGRNGRLRVGRERPVLGESP (Heffernan et al. 2012)

GYLLGHINLHHLAHL-Aib-HHIL (Chen et al. 2017a)

PKKGSKKAVTKAQKKDGA (Kochurani et al. 2015)

GWTLNSAGYLLGKINLKALAALAKKIL, TP (Pooga et al. 1998)

AGYLLGKINLKALAALAKKIL (Soomets et al. 2000)

VRRFkWWWkFLRR (Bahnsen et al. 2015)

KWCFRVCYRGICYRRCRGK (Jain et al. 2015)

TKDNNLLGRFELSG (Gehrmann et al. 2014)

CKRGARSTA (Paasonen et al. 2016)

INWKKWWQVFYTVV (Dias et al. 2017)

RRLTLRQLLGLGSRRRRRSR (Dias et al. 2017)

WRRRYRRWRRRRRWRRRPRR (Dias et al. 2017)

MAVPPTYADLGKSARDVFTKGYGFGL (Smilansky et al. 2015)

NAATATRGRSAASRPTQRPRAPARSASRPRRPVQ (Elliott and O’Hare, 1997)

TVDNPASTTNKDKLFAVRK (Manosroi et al. 2014)

DPKGDPKGVTVTVTVTVTGKGDPKPD (Oehlke et al. 1997)

W(RW)4 (Nasrolahi Shirazi et al. 2013)

LCLR (Montrose et al. 2014)

MAARLC (Adachi et al. 2017)

YKALRISRKLAK (Desai et al. 2014)

YTAIAWVKAFIRKLRK (Lindgren et al. 2006)

IAWVKAFIRKLRKGPLG (Lindgren et al. 2006)

FWIGGFIKKLKRSKLA (Chen et al. 2017c)

FKIKKFIGGLWRSKLA (Chen et al. 2017c)

KRYKNRVASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLK(Derouazi et al. 2015)

FKIGGFIKKLWRSKLA (Chen et al. 2017c)

备注:Ac=acetyl; Ahx or X=aminohexanoic acid; Aib=aminoisobutyric acid; B=β-alanine; Bpg=bishomopropargylglycine; Dmt=dimethyltyrosine; O=ornithine; pT=phosphoryl-Thr; pS=phosphoryl-Ser; Φ=l-2-naphthylalanine; ri=retro-inverso; *=staple tethering site。