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Peptide Modifications

Peptide modifications are playing more and more important roles in our research, we can change the physical and chemical property of peptide by modifying its structure and active group. Structure modification includes MAPs, cyclizing, stamped peptide etc; Active group modification includes C-terminal modification, N-terminal modification and side-chain group modification etc.
        With many years of practical peptide synthesis and research experience, HongTide have developed specific skills and expertise for making modified and difficult-to-synthesize peptides in excellent quality, we can offers hundreds of peptide modifications such as Fluorescence and Dye Labeling Peptides, Cyclic Peptides Synthesis, Phosphopeptides etc. to meet custom peptide requirements. These peptide modifications can be used to create synthetic peptide with the exact conformation for specific applications. Our highly skilled and experienced staff ensures that the most appropriate methods and techniques are selected for each custom peptide project. HongTide are your best choice for producing custom modified peptides on time and on budget. Our peptide modifications services including but not limited to the following:

  • Fluorescent Dye-Labels

    We manufacture custom peptides with a broad range of flurescent dys such as FITC, CY5, rhB etc.

  • FRET Substrates

    We offer a full-range of dye-quencher FRET pairs to label your custom peptide.

  • Phosphorylation

    We can synthesize phosphorylation peptides from one to five phosphorylation sites with high quality and sulfonation peptides as well.

  • Isotope Labeling

    We can manufacture peptides labed with C13, N14, which are widely used at MS and NMR quantitative analysis.

  • Stapled Peptides

    We offer an adaptable platform for the custom synthesis of stapled peptides catering to a variety of biological applications.

  • Disulfide Bridges

    We produce disulfide bridged peptides, utilizes stepwise protection or natural folding strategies.

  • Amide Cyclization

    We offer a versatile platform for the synthesis of lactam ring cyclic peptides.

  • Peptide Libraries

    We produce and deliver peptide libraries in a convenient 96-well plate format adapted to high-throughput screening.

  • Glycosylation

    Sugar moieties can be incorporated into your custom peptide(s), at single or multiple locations.

  • Lipopeptides

    We have developed novel methods for the synthesis and purification of hydrophobic peptide modifications.

  • PEGylation

    We can perform site-specific PEGylation at a variety of sites on the peptide for your research.

  • Peptoids

    Peptoids can enhance binding affinities, lower cytotoxicity, better solubility, and increased cell-permeability. We can manufacture large range of peptoids.

  • Unnatural Amino Acids

    Through cooperating with qualified building block suppliers, we can maunfacture peptide with large amount of unnatural amino acids.

  • MAPs

    We use Lys residues as the scaffolding core to support the formation ≤8 branches with varying or the same peptide sequences.

  • Linker Spacer

    We can modify many kinds of linkers and spacers to custom peptides such as PEG, Ahx etc.

  • Cell-penetrating peptides

    Cell-Penetrating Peptides (CPPs) is known as protein transduction domains (PTDs), membrane translocating sequences (MTSs) or Trojan peptides.

  • Chelating Peptides

    We can conjugate many metal chelates to custom peptides such as DOTA, NOTA, DTPA, TETA etc.

  • Insoluble Peptide Purification

    We have rich experience on insoluble peptide purification which can enhance the success ratio of peptide synthesis.

  • Long Peptide Synthesis

    We has experience in the synthesis of long peptide sequences. We employ a variety of strategies to overcome poor solvation and aggregation.

  • N-terminal modifications

    We can offer full arrange of N-terminal modifications such as D-Biotin, acetyl, azidation etc.

  • C-terminal modifications

    We can offer full arrange of C-terminal modifications such as AMC, pNA, EDDnp etc.

How to place a order
1)Contact us at: +86-(0)-19961912513 or sales@hongtide.com;
2)Provide us peptides information including Sequence, Purity, Quantity and modification(If necessary, we agree to sign confidential agreement with you before you provide these information), we will make you a quotes within 30 minutes.
3)Place us a purchaser order, we can send you a sales contract too if you need.
4)Start synthesis, and we will inform you the updates of synthesis in time.
5)Arrange shippment, HPLC analysis, MS spectrum will be shipped along the peptides too.
6)Refund all pre-payment(if pre-pay us) if we failed to synthesize any of them.
7)After-sale service: Contact us anytime if you have any problem when you use the peptides, and we will reply you as soon as possible.